Greenpoint is the northernmost neighborhood in the New York City borough of Brooklyn, in the U.S. state of New York. It is bordered on the southwest by Williamsburg at Bushwick Inlet Park and McCarren Park; on the southeast by the Brooklyn-Queens Expressway and East Williamsburg; on the north by Newtown Creek and the neighborhood of Long Island City in Queens; and on the west by the East River.

Originally farmland – many of the farm owners' family names, such as Meserole (Messerole) and Calyer, are current street names – the residential core of Greenpoint was built on parcels divided during the 19th century, with rope factories and lumber yards lining the East River to the west, while the northeastern section along the Newtown Creek through East Williamsburg became an industrial maritime area.

Greenpoint is part of Brooklyn Community District 1 and its primary ZIP Code is 11222. It is patrolled by the 94th Precinct of the New York City Police Department.