Midtown Manhattan is the central portion of the borough of Manhattan in New York City. Midtown is home to some of the city's most iconic buildings, including the Empire State Building, the Chrysler Building, the Hudson Yards Redevelopment Project, the headquarters of the United Nations, Grand Central Terminal, and Rockefeller Center, as well as Broadway and Times Square.

Geographically, the northern bound of Midtown Manhattan is commonly defined to be 59th Street; its southern boundary is less clear, and variously taken to be 34th Street, 23rd Street, or even 14th Street. Midtown spans the entire island of Manhattan along an east-west axis, bounded by the East River on its east and the Hudson River to its west. The Encyclopedia of New York City defines Midtown as extending from 34th Street to 59th Street and from 3rd Avenue to 8th Avenue.

Midtown is part of Manhattan Community District 5. It is patrolled by the 14th and 18th Precincts of the New York City Police Department.