Prospect Lefferts Gardens is a residential neighborhood in the Flatbush area of the New York City borough of Brooklyn. The community is bounded by Empire Boulevard (formerly Malbone Street) to the north, Clarkson Avenue to the south, New York Avenue to the east, and Ocean Avenue/Prospect Park to the west. Prospect Lefferts Gardens was designated a NYC Landmark area in 1979 and called the Prospect Lefferts Gardens Historic District.

Prospect Lefferts Gardens is part of Brooklyn Community District 9 and its primary ZIP Code is 11225. It is patrolled by the 71st Precinct of the New York City Police Department. Politically it is represented by the New York City Council's 40th District.